… inhibition of bromodomain-containing protein 4 (Brd4) in UUO, a protein that upregulates the
transcriptional activity of NOX4… , SOD 1, and 2 expressions, with attenuation of H 2 O 2 and …

… First, we investigated whether Brd4 regulates Nox4 gene expression. Primary IPF lung …
We demonstrate that Brd4 inhibition partially blocks p300 recruitment/stabilization, and its …

… can attenuate renal injury and fibrosis in the UUO model. … fibrosis in the UUO model [67,68].
In this study, we observed that CS treatment reduced NOX4 mRNA and protein expression in …

… have shown that blockade of HDAC6 with ACY-1215 also attenuated renal fibrosis through
a … Brd2, Brd3, and Brd4 are ubiquitously expressed but Brdt is only expressed in the male …

… In prostate cancer, BRD4 inhibitors block mitochondrial … and protein expression observed 5
days after unilateral ureteral … in rats described that Brd4 regulation with jQ1 diminished Nox4-…

… lung fibrosis through transcriptional elongation [13]. Also, BRD4 inhibition attenuates
cardiomyocyte … BRD4 modulated Nox4 expression to block TGF-β1-induced oxidative stress and …

… pharmacological inhibition of PAR-1 by vorapaxar attenuated … Expression of Nox4 is up-regulated
in UUO-induced fibrotic … its inhibition by vorapaxar inhibited TGF-β-mediated ECM …

… the Nox4 promoter in a BRD4-dependent manner and increasing … by which BRD4 inhibition
blocks TGF-β-mediated EndMT is by … In addition to attenuating EndMT, BRD4 inhibition also …

… Inhibition of BRD4 attenuated renal fibrosis by blocking TGF-β-mediated Nox4 expression
[… Another study showed that suppression of BRD4 by JQ1 robustly blocked TGFBR2 level in …

… that the BRD4 inhibitor JQ1 controlled SOX9 expression via … Several studies have confirmed
that JQ1 attenuated fibrosis … silencing, and the downregulation of SMAD signaling, blocked …